Newborn screening: rationale for a comprehensive, fully integrated public health system
McCabe, Linda L.
Bradford L., Therrell Jr.
McCabe, Edward R.B.
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Newborn screening has existed for approximately four decades . During that period of time, newborn screening has evolved conceptually from a laboratory test for a single disorder, phenylketonuria (PKU), to a multi-part public health system involving education, screening, diagnostic follow-up, treatment/management, and system evaluation [2–5]. At a time when newborn screening is recognized as a model for predictive medicine [6,7], it also faces critical challenges that will determine its future credibility and viability. In order to understand these challenges, it is helpful to review briefly the history of newborn screening.